There is no one who is insignificant in the purpose of God.
God has accomplished much through individuals society has deemed insignificant. Therefore, no one is insignificant in the eyes of God. Look for the value in those around you, including yourself. We all have a meaningful role in fulfilling the purpose of God.
And we know that for those who love God all things work together for good, for those who are called according to his purpose.
Romans 8:28 (NABRE)